List of  Publications of  Radiopharmaceuticals, Immunoassay, Labelled Compounds & Jonaki

List of Thesis

 M.Sc. (By Research)

 1.         Investigations of immunological methods of hormone analysis (1989)

Shubhangi Mirapurkar nee Rekha Lokhande

 2.         Studies on evaluation of radiochemical purity of radiopharmaceuticals used in the

              hospital pharmacy (1998)

             D.K. Ranganatha

 3.         Radiochemical analysis of the purity and stability of ^99mTc phosphates and     

              phosphonates.

             Nandini P. Joshi (1998)

 4.         Development of T₃ uptake test using anti-T₃ antibody.

Rani Gnanasekar (1999)

 5.        Application of monoclonal antibodies for development of human follicle simulating

             hormone (FSH) assay based on solid phase separation technique.

 Shalaka N. Paradkar

 6.         Radiolabelling of proteins with ^99mTc for possible inflammation imaging

Jayula S. Sarnaik

 7.         Fabrication of radiation sources including substrate preparation for use in industry

             and nuclear medicine

 P.S. Balasubramanian

 Ph.D. Theses

 1.         Studies on the labelling of some biomolecules (1989)

N. Jyotsna

 2.        Studies on nuclear data relevant to the cyclotron production of radionuclides of

            medical interest (1990)

M.K. Das.

 3.         Studies on the enzyme labelled compounds for the development of enzyme

             immunoassay (1992)

Jyoti M. Shetye

 4.         Studies on radiolabelling of immunoglobulin G (lgG) for in-vivo applications (1995)

Amita A. Bhelose

 5.         Studies on the use of Staphylococcal Protein A in Immunoassays (1997)

Sangeeta H. Joshi

6.         Preparation and evaluation of a few compounds of ^99m Tc of biomedical interest (1999)

R. Vanaja

7.         Studies on radiochemical separation and purity assessment of relevance to preparation of important medical radionuclides following charged particle irradiation.

8.         Radioimmunoassay of the drug using ¹²⁵_I as a label.

9.         Development of magnetizable immunosorbents for radioanalytical estimation and separation of hormones.

Vijay B. Kadwad

10.       Studies on the separation and evaluation of Technetium-99m : Applicability to ⁹⁹Mo- ^99mTc generator for medical use.

Saraswathy Padmanabhan

11.       Studies on the formulation, separation and evaluation of ^99mTc compounds - Applicability for ^99mTc radiopharmaceuticals and hospital radiopharmacy.

Prakash M. Pandey

Publications from Radiopharmaceuticals Programme Unit, BRIT

A)    Books/Manuals

1.         Radioimmunoassay - An Update : Proc. of a BRNS/DAE Seminar

N. Sivaprasad, N. Ramamoorthy, C.N. Desai - Editors

BRIT, DAE, Bombay 1995.

2.         Hospital Radiopharmacy Practices in India

N. Ramamoorthy and C.N. Desai - Editors

Manual for Accreditation of Hospital Radiopharmacists

RPC/BRNS-DAE, BRIT, Mumbai, 1997.

Journals, Books and Manuals

1.         Yields of some radioisotopes formed in  a-particle induced reactions on natural molybdenum

M.K. Das, B.R. Sarkar, N. Ramamoorthy, R.S. Mani

Radiochimica Acta 47, 29-32, 1989.

2.         Yield of ⁵²Fe by a-particle reaction on natural chromium at 70 MeV

M.K. Das, N. Ramamoorthy, B.R. Sarkar, R.S. Mani ibid 47, 173-175, 1989.

3.         Preparation and evaluation of ^99mTc-thiodiglycolic acid (TDGA) as a possible renal function agent

N. Ramamoorthy, S.A. Balakrishnan, S.V. Shetye, P.M. Pandey, U.N. Nayak, R.B. Patel, M.C. Patel, P. Ramanathan

.Radioanal.Nucl.Chem. Articles 134, 423-431, 1989.

4.         Shaking polystyrene beads during coating with antibody : Effect on the precision profile of enzyme immunoassay of T3, Kanchan Kothari, N. Sivaprasad, R.S. Mani

Clin. Chem. 701, 35, 1989.

5.         Studies on the calibration curves of human placental lactogen

N. Sivaprasad, R.S. Mani

Ind. J. Nucl. Med. 30, 4, 1989.

6.       Technetium-99m radiopharmaceuticals and kits for their preparation, N. Ramamoorthy, ibid, pp 101-108

7.       Some aspects of optimization of separation system in radioimmunoassay of triodothyronine

Rathinaswamy, U.H. Nagvekar, S.D. Borkute, S.A. Balakrishnan, C.N. Desai

J.Radioanal.Nucl.Chem.Articles, 139, 215-221, 1990.

8.         Preparation and evaluation of technetium-99m-t-butyl-isonitrile (Tc-TBI) for myocardial imaging : Kit for hospital radiopharmacy

S.S. Sachdev, N. Ramamoorthy, U.N. Nayak, R.B. Patel, P. Ramanathan, Seema Srivastava, Ramji Lal, S.V. Raghavan, K.B. Shah, C.N. Desai

Nucl.Med.Biol. 17, 543-552, 1990.

9.         Yields of some radioisotopes formed in   a-particle induced reations on titanium and recovery of scandium radionuclides M.K. Das, B.R. Sarkar, N. Ramamoorthy, Radiochimica Acta 50, 135-139, 1990.

10.       Visualisation of suppressed thyroid tissue by ^99mTc-t-butylisonitrile : An alternative to post TSH stimulation scanning

P. Ramanathan, R.B. Patel, N. Subrahmanyam, U.N. Nayak, S.S. Sachdev, N. Ramamoorthy, J. Nucl.Med.31, 1163-1165, 1990.

11.       A novel technique for the separation of ^99mTc from ⁹⁹Mo

S.N. Muddukrishna, D.V.S. Narasimhan, C.N. Desai

J. Radioanal.Nucl.Chem., Articles, 140, 153-157, 1990.

12.       Extraction of ^99mTc into MEK from large quantity of molybdate retained on alumina column.

S.N. Muddukrishna, D.V.S. Narasimhan, C.N. Desai.

J.Radioanal. Nucl. Chem., Letters, 145, 311-320, 1990.

13.       A rapid method for recovery of radiochemically pure Tc-99m from MEK

S.N. Muddukrishna, D.V.S. Narasimhan, P. Saraswathy, C.N. Desai

J. Radioanal. Nucl. Chem., Letters, 146, 235, 1990.

14.       Radiopharmacy, N. Ramamoorthy in Nuclear Medicine Technology : An Update, Course Book of a BRNS/DAE-NMC Workshop, Calcutta, 1990.

15.       Studies on the stability of Tc-d, I-HMPAO in aqueous solution

K. Tubergen, M. Corlija, N. Ramamoorthy, M.R.A. Pillai, W.A. Volkert, D.E. Troutner, R.A. Holmes

J.Lab.Comp. Radiopharm. 30, 50-51, 1991.

16.       Suitability of PEG for precipitation of monoclonal antibodies (MoAb) - A radiometric study

Rathinaswamy, U.H. Nagvekar, J. Chatur, N. Ramamoorthy, C.N. Desai

Appl. Radiat. Isot., 42, 206-207, 1991.

17.       Superiority of the use of pre-incubated complex of primary and second antibody in the RIA of thyroid hormones.

Rathinaswamy, U.H. Nagvekar, V. Mirmala, J. Chatur, K. Rani, N. Ramamoorthy, S.A. Balakrishnan, C.N. Desai, Nucl.Med.Biol. 18, 187-189, 1991.

18.       Developments in Radiopharmaceuticals for Diagnosis, N. Ramamoorthy, Ind.J.Nucl.Med. 6, 14-20, 1991.

19.      Developments in Radiopharmaceuticals for Therapy D.V.S. Narasimhan, Ind.J.Nucl.Med. 6, 21-25, 1991.

 20.     Separation of ²¹¹At form irradiated bismuth target and labelling of a model protein,
         M.K. Das, B.R. Sarkar, N. Ramamoorthy, C.N. Desai, Ind. J. Phys. 65A, 575-578, 1991.

 21.    Development of a heterologous radioimmunoassay of human prolactin, K.K. Kothari,
          V. Meera, P.D. Soman, R. Lal, N. Sivaprasad, Ind. J. Nucl. Med. 6, 27-32, 1991.

22. 

23.      Utility of technetium-t-butylisonitrile (^99mTc-TBI) myocardial imaging in coronary artery
           disease, N. Nair, U.N. Nayak, P. Ramanathan, N. Ramamoorthy, S.S. Sachdev

Nucl. Med. Biol. 19, 705-709, 1992.

 24.     Synthesis and Evaluation of ^99mTc monocationic mixed ligand complexes of phenyl      
           substituted/condensed tetradentate Schiff's bases and trimethyl phosphine

N.C. Goomer, P.V. Kulkarni, R.W. Parkey et al.
 

Nucl.Med. Biol. 19, 679-684, 1992.

 25.       Radioimmunoassay of phenytoin

G. Samuel, N. Sivaprasad, R.S. Mani

J. Radioanal. Nucl. Chem. 216, 149, 1992.

 26.       Radioimmunoassay of drugs: phenytoin, clonidine and theophylline

G. Samuel, N. Sivaprasad, M. Venkatesh, R. Mathew, P. Vavia, H.L. Bhalla in "Developments in radioimmunoassay and related procedures: Perspectives in developing countries", IAEA, Vienna, 1992, pp.135-147.

 27.       Development of enzymeimmunoassay for determination of triiodothyronine,  thyroxine and human placental lactogen in serum samples and comparison with radioimmunoassay

K. Kothari, Meera Venkatesh, Aruna Korde, N. Sivaprasad, ibid, pp.

503-514

 28.       Radioimmunoassay (RIA) - Recent Developments

N. Sivaprasad, N. Jyotsna, U.H. Nagvekar in "Practice of Radioimmunoassay (RIA) and Immunoradiometric assay (IRMA) - an Update", DAE/BRNS, BRIT, Bombay, 1992.

 29.       Standards, N. Sivaprasad, ibid, 1992.

 30.       The Solid phase separation systems in RIA and IRMA, N. Jyotsna, ibid, 1992.

 31.       Trouble shooting in Radioimmunoassay, V. Bhupal , ibid, 1992.

 32.       Evaluation of commercial kits, N. Sivaprasad, ibid, 1992.

 33.       Good lab management and practices in RIA and Sources of errors, V. Bhupal, ibid, 1992.

 34.       Optimisation of labelling of RBC with ^99mTc using a new kit of stannous pyrophosphate, B.P. Tiwari, P. Ramanathan, N. Mundle, S.V. Raghavan, N. Ramamoorthy, Ind.J.Nucl.Med. 8(3), 11-15, 1993.

 35.       Quality management of radiopharmaceuticals, K.B. Shah

Ind. J. Nucl. Med., 9(4), 230-237, 1994.

 36.       New radiopharmaceuticals for nuclear medicine procedures, N. Ramamoorthy, R. Vanaja, P.M. Pandey in AERB-BRNS/DAE Course Manual on "Radiation safety in nuclear medicine lab. - an update", BARC, Bombay, 1994, pp. 72-78.

 37.       Synthesis of bulk reagents and production and evaluation of Tc-99m radiopharmaceuticals and kits, N. Ramamoorthy, S. Chattopadhyay, S.S. Sachdev, R. Vanaja, P.M. Pandey, D.K. Ranaganatha, S.V. Raghavan, Ramji Lal, in  ^99mTc radiopharmaceuticals for brain, heart and kidney imaging", IAEA-TECDOC-805, IAEA, Vienna (1995) pp.18-21.

 Procedures for production of ^99mTc generators based on ⁹⁹Mo conversion to zirconium molybdate, D.V.S. Narasimhan, P. Saraswathy, L.N. Singh, R.R. Patel, S.K. Sarkar, in "Alternate technologies for ^99mTc generators" IAEA-TECDOC-852, 1995, pp.23-28.

 Procedures for production of ^99mTc generators based on neutron activation of titanium molybdate, D.V.S. Narasimhan, P. Saraswathy, L.N. Singh, R.R. Patel, S.K. Sarkar ibid. pp.33-34.

 38.       ⁶⁷Ga-Gallium cirate: 1 : Production experience at VECC, Calcutta.

M.K. Das, N. Ramamoorthy Ind. J. Nucl. Med. 10, 63-66, 1995.

 Radiopharmaceuticals, N. Ramamoorthy, in Thematic Bulletin on "Nuclear Medicine", IANCAS, Bombay (1995) pp. 11-19.

 39.       Evaluation of some magnetizable immunoadsorbents in RIA and IRMA of hormones, N. Jyotsna, V. Kadwad, N. Sivaprasad, V. Nirmala, N.Pal, Yojana Singh, T.K. Karir, Vrinda C, Shalaka N. Paradkar, IAEA-TECDOC 914, 1996, pp.69-77.

 40.       Anomalies in hepatobiliary excretion of ^99mTc-MAG3, M. Chatterjee, A. Majumdar, Priya Iyer, G. Muthukrishnan, M.K. Das, N. Ramamoorthy, C.N. Desai, S. Banerjee, Nucle.Med.Biol. 23, 867-872, 1996.

 41.       A method of preparation of magnetizable cellulose and its application in RIA of T3 and T4, V. Kadwad, N. Jyotsna, N. Sivaprasad, P.K. Sinha, J. Radioanal.Nucl.Chem.Articles, 210, 27-33, 1996.

 42.       Synthesis of an immunogen and a novel radiotracer of estradiol, A.G. Sapre, Ramji Lal, N. Sivaprasad, P.R. Vavia, J. Radioanal. Nucl. Chem. Letters, 214, 291-301, 1996.

 43.       A cation exchange method for separation of ¹¹¹In from inactive silver, copper, traces of iron and radioactive gallium and zinc isotopes, M.K. Das, S. Chattopadhyay, B.R. Sarkar, N. Ramamoorthy, Appl. Radiat. Isot. 48, 11-14, 1997.

 44.       Simple procedure for the preparation of iron-free ⁶⁷Ga from an irradiated copper target - Use of ascorbic acid, S. Chattopadhyay, M.K. Das, B.R. Sarkar, N. Ramamoorthy, Appl. Radiat. Isot. 48, 211-212, 1997.

 45.       Radiochemical separation of high purity ¹¹¹In from cadmium, copper, aluminium and traces of iron: Use of a cation exchange resin with hydrobromic acid and hydrochloric acid, S. Chattopadhyay, M.K. Das, B.R. Sarkar, N. Ramamoorthy, Appl. Radiat. Isot. 48, 1063-1067, 1997.

 Formulation and evaluation of two components lyophilized kit for ^99mTc-sestamibi: Transchelation preparation of ^99mTc-sestamibi, P.M. Pandey, S.S. Sachdev, R. Ramamoorthy, R. Lal, D.K. Ranganatha, S. Narasimhan, R. Oommen, N.A. Nair, S. Gunasekaran, Nucl. Med. Biol. 24, 697-700, 1997.

 46.       Development of radioimmunoassay : I : Preparation of radiolabelled tracer theophylline, H.L. Bhalla, P.R. Vavia, G. Samuel, N. Sivaprasad, J. Radioanal. Nucl. Chem. 220, 73-76, 1997.

 47.       Preparation of radiolabelled clonidine for use in radioimmunoassay, H.L. Bhalla, R. Mathew, Grace Samuel, N. Sivaprasad, J. Radioanal. Nucl. Chem. 221, 93-95, 1997.

 48.       Radiopharmaceuticals in nuclear oncology - Status and Recent Trends, N. Ramamoorthy, G. Prabhakar in "Nuclear Medicine in Oncology", Course Book of a BRNS/DAE-NMC Workshop, Trivandrum, 1997, pp.1-6.

 49.       Radioiodination of low potency HGH and its characterisation, T.K. Karir, Yojana Singh, N. Jyotsna, N. Sivaprasad, Ind. J. Nucl. Med., 12, 16-19, 1997.

 50.       Radiopharmaceitocals for Oncology : Status and Newer Trends - An Overview, N. Ramamoorthy, G. Prabhakar, Ind. J. Nucl. Med. 12, 97-103, 1997.

 51.       Isoniazide, A drug for tuberculosis (TB), S.D. Borkute, N. Sivaprasad, S.A. Balakrishnan, Indian Drugs, 34, 1-10, 1997.

 52.       Development of a sensitive ¹²⁵I thyroid monitoring system suitable for production plant environment, T.B. Bhargava, P.M. Ravi, A.M. Bhagwat, S.B. Kamble, S.S. Arora, Radiation Protection and Environment, 20, 29-32, 1997.

 53.       Preparation and evaluation of ¹⁵³Sm-EDTMP using natural Sm₂O₃ targets - Applicability for palliative treatment of metastatic bone pain, P. Saraswathy, D.V.S. Narasimhan, P.S. Balasubramanian, D.K. Ranganatha, U.N. Nayak, R.B. Patel, P. Ramanathan, Ind. J. Nucl. Med. 12, 191-197, 1997.

 54.       Radionuclides in Medicine and Research, N. Ramamoorthy in "Radiation Safety for Unsealed sources", G.S. Pant, Ed., Himalaya Publishing House, New Delhi, 1998, pp.77-82.

 55.       Estimation of Thyroid Hormones in Animal Samples, B. Premkumar David, R. Vijayakumar, K.S. Palaniswami, V.B. Kadwad, N. Sivaprasad, Ind. Vet. J. 75, 565-566, 1998.

 56.       ^99mTc complexes for functional imaging - Genesis of development and Recent trends, N. Ramamoorthy, Ind. J. Nucl. Med. 13, 79-94, 1998.

 57.       Radiopharmaceuticals Scenario-1998, N. Ramamoorthy, V. Meera, O.P.D. Noronha, Ind. J. Nucl. Med. 13, 95-104, 1998.

 58.       Getting higher yields of monoclonal antibody in culture.

Prabuddha K. Kundu, N. Sivaprasad, S.E. Electricwala, Raghav Varma, Debatosh Datta, Ind. J. Physiol. Pharmacol., 42(2) 155-171, 1998.

 59.       Monoclonal Ab : High density culture of hybridoma cell and downstream processing for IgG Ind. J. Exp. Biology, 36, 125-135, 1998.

 60.       ^99mTc gel generators based on zirconium molybdate ⁹⁹Mo : I : Process standardisation for production, P. Saraswathy, S.K. Sarkar, R.R. Patel, S.S. Arora, D.V.S. Narasimhan, Radiochimica Acta, 83, 97-102, 1998.

 61.       ^99mTc gel generators based on zirconium molybdate ⁹⁹Mo : II : Evaluation of preparation and performance, P. Saraswathy, S.K. Sarkar, N. Ramamoorthy, G. Arjun, R.R. Patel, Radiochimica Acta, 83, 103-107, 1998.

 62.       Radiometric Studies on Adsorption of Iron on Cation Exchange Resin and also of Indium and Gallium in the Presence of Iron: Applicability to Prepare ⁶⁷Ga of Low Iron Content, S. Chattopadhyay, M.K. Das, B.R. Sarkar, N. Ramamoorthy, Appl. Radiat. Isot.49, 899-902, 1998.

 63.       Radioassay for estimation of higG using Staphylococcal protein A as a binding agent, Sangeeta H. Joshi, N. Sivaprasad, Indian Drugs, 35 (8), 494-498, 1998.

 64.       Microwave oven drying of zirconium molybdate - ⁹⁹Mo for use in ^99mTc gel generator, P. Saraswathy, S.K. Sarkar, D.V.S. Narasimhan, R.R. Patel, N. Ramamoorthy, Appl. Radiat.Isot. 50, 277-281, 1999.

 65.       Evaluation of radioiodination of metaiodobenzyl guanidine (MIBG) catalysed by in situ generated Cu(I) and directly added Cu(II), G. Prabhakar, K.S. Mehra, R. Ramamoorthy, S. Chattopadhyay, Reji Oommen, S. Narasimhan, N.A. Nair, S. Gunasekaran, Appl. Radiat. Isot. (In Press, 1999).

 66.       A Paper Chromatographic Technique for Quantitative Evaluation of Hydrolysed and Ionic Component in ²⁰¹TL Radiopharmaceuticals, S. Chattopadhyay, M.K. Das, B.R. Sarkar, N. Ramamoorthy, Appl. Radiat. Isot., (In Presss, 1999).

 67.       Radioiodination of recombinant human growth hormone and its use in radioimmunoassay, T.K. Karir, S.M. Mirapurkar, N. Jyotsna, N. Sivaprasad, J. Radioanal. Nucl. Chem. Letters, 240, 343-347, 1999.

 68.       Nature of immunoglobulins and methods of estimation of immunoglobulin G, Sangeetha H. Joshi, N. Sivaprasad, N. Ramamoorthy, Varalakshmi Elango, Indian Drugs.

 69.       Deveopment of radioimmunoassay of triiodothyronine (T3) using magnetized cellulose, S.M. Mirapurkar, N. Jyotsna, N. Sivaprasad, Ind. J. Nucl. Med.

 70.       An IRMA for hFSH using a monoclonal antibody coupled to magnetisable cellulose, S.N. Paradkar, Vrinda C., N. Jyotsna, N. Sivaprasad, J. Radioanal. Nucl. Chem.